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Pfizer (NYSE:PFE) Stock Signal: How Will China’s GLP-1 Approval Counter the Massive Patent Cliff and Struggling Pipeline?

By Adam Lemon
Chief Analyst and Director of Content

Adam Lemon began his role at DailyForex in 2013 when he was brought in as an in-house Chief Analyst. Adam trades Forex, stocks and other instruments in his own account. Adam believes that it is very possible for retail traders/investors to secure a positive return over time provided they limit their risks, follow trends, and persevere through short-term losing streaks – provided only reputable brokerages are used. He has previously worked with...

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Short Trade Idea

Enter your short position between $26.78 (the intra-day high of its last bearish candlestick) and $27.17 (an intermediate horizontal resistance level).

Market Index Analysis

  • Pfizer (PFE) is a member of the S&P 100 Index and the S&P 500 Index.

  • Both indices trade inside bearish price channels with rising bearish trading volumes.

  • The Bull Bear Power Indicator of the S&P 500 Index is bearish with a descending trendline.

Market Sentiment Analysis

Equity futures point to another bearish start to the trading session, building on last week’s massive sell-off, as the US-led war against Iran entered its second week. Oil futures spiked to nearly $120 per barrel as the quasi-closure of the Strait of Hormuz forced major oil producers to slash production. Should oil prices remain elevated for a prolonged period, it could tip the global economy into a recession, spike inflation, and raise borrowing costs. On the economic front, markets eagerly await Wednesday’s CPI and Friday’s PCI reports. Hewlett-Packard Enterprise, Oracle, Adobe, and Dick’s Sporting Goods highlight the earnings calendar.

Pfizer Fundamental Analysis

Pfizer is a multinational pharmaceutical and biotechnology company. It specializes in immunology, oncology, cardiology, endocrinology, and neurology. PFE also ranks fifth among the most prominent biomedical companies by revenue.

So, why am I bearish on PFE despite the GLP-1 approval in China?

The approval of Pfizer’s Severwin in China provides a short-term boost, but I believe it will fail to offset the massive patent cliff for key drugs like Eliquis, Xeljanz, and Ibrance, which could wipe out $1.5 billion in revenues in 2026 and $3.0 billion in 2027. Positive Phase 3 trial results for PADCEV are overshadowed by the discontinuation of danuglipron and the pause of two Seagen pipeline assets. I am equally worried about the 2,100+ Depo-Provera lawsuits, and margin pressures despite its nearly $8 billion in planned cost cuts by 2027.

Metric
Value
Verdict
P/E Ratio
19.89
Bullish
P/B Ratio
1.78
Bullish
PEG Ratio
13.77
Bearish
Current Ratio
1.16
Bearish
ROIC-WACC Ratio
Positive
Bullish

Pfizer Fundamental Analysis Snapshot

The price-to-earnings (P/E) ratio of 19.89 makes PFE an inexpensive stock. By comparison, the P/E ratio for the S&P 500 Index is 26.63.

The average analyst price target for PFE is $28.43. This suggests that there is limited upside potential with rising downside risk.

Pfizer Technical Analysis

Today’s PFE Signal

PFE030926

Pfizer Price Chart

  • The PFE D1 chart shows price action inside a bearish price channel.

  • It also shows price action between its ascending 38.2% and 50.0% Fibonacci Retracement Fan levels.

  • The Bull Bear Power Indicator is bearish with a descending trendline.

  • The average bearish trading volumes are higher than the average bullish trading volumes.

  • PFE corrected with the S&P 500 Index, a bearish confirmation.

My PFE Short Stock Trade

  • PFE Entry Level: Between $26.78 and $27.17

  • PFE Take Profit: Between $23.11 and $23.91

  • PFE Stop Loss: Between $27.94 and $28.43

  • Risk/Reward Ratio: 3.16

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Chief Analyst and Director of Content

Adam Lemon began his role at DailyForex in 2013 when he was brought in as an in-house Chief Analyst. Adam trades Forex, stocks and other instruments in his own account. Adam believes that it is very possible for retail traders/investors to secure a positive return over time provided they limit their risks, follow trends, and persevere through short-term losing streaks – provided only reputable brokerages are used. He has previously worked within financial markets over a 12-year period, including 6 years with Merrill Lynch.

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